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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50024845
Substrate
n/a
Meas. Tech.
ChEMBL_3944 (CHEMBL619944)
IC50
2540±n/a nM
Citation
 Buckle, DR; Foster, KA; Taylor, JF; Tedder, JM; Thody, VE; Webster, RA; Bermudez, J; Markwell, RE; Smith, SA Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity. J Med Chem 30:2216-21 (1988) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT
Type:
PROTEIN
Mol. Mass.:
78082.31
Organism:
Rattus norvegicus
Description:
ChEMBL_1432947
Residue:
673
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDEELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFHIHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEAIQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50024845
Synonyms:
7-Methyl-2-(4-methyl-benzyl)-1H-benzoimidazol-4-ol | CHEMBL303956
Type:
Small organic molecule
Emp. Form.:
C16H16N2O
Mol. Mass.:
252.311
SMILES:
Cc1ccc(Cc2nc3c(O)ccc(C)c3[nH]2)cc1
Structure:
Search PDB for entries with ligand similarity: