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Target
Thromboxane-A synthase
Ligand
BDBM50024903
Substrate
n/a
Meas. Tech.
ChEMBL_210118 (CHEMBL814434)
IC50
7±n/a nM
Citation
 Wright, WB; Tomcufcik, AS; Chan, PS; Marsico, JW; Press, JB Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones. J Med Chem 30:2277-83 (1988) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1
Type:
PROTEIN
Mol. Mass.:
59971.80
Organism:
Rattus norvegicus
Description:
ChEMBL_209768
Residue:
533
Sequence:
MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
  
Inhibitor
Name:
BDBM50024903
Synonyms:
6-Chloro-3-(4-imidazol-1-yl-butyl)-1H-quinazoline-2,4-dione; hydrochloride | CHEMBL541827 | CHEMBL75787
Type:
Small organic molecule
Emp. Form.:
C15H15ClN4O2
Mol. Mass.:
318.758
SMILES:
Clc1ccc2[nH]c(=O)n(CCCCn3ccnc3)c(=O)c2c1
Structure:
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