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Target
Carbonic anhydrase 2
Ligand
BDBM50024219
Substrate
n/a
Meas. Tech.
ChEMBL_45069 (CHEMBL659852)
Ki
14±n/a nM
Citation
 Ponticello, GS; Freedman, MB; Habecker, CN; Lyle, PA; Schwam, H; Varga, SL; Christy, ME; Randall, WC; Baldwin, JJ Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors. J Med Chem 30:591-7 (1987) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50024219
Synonyms:
4,4,7-Trioxo-4,5,6,7-tetrahydro-4lambda*6*-thieno[3,2-b]thiopyran-2-sulfonic acid amide | CHEMBL158090
Type:
Small organic molecule
Emp. Form.:
C7H7NO5S3
Mol. Mass.:
281.329
SMILES:
NS(=O)(=O)c1cc2c(s1)C(=O)CCS2(=O)=O
Structure:
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