Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50024223
Substrate
n/a
Meas. Tech.
ChEBML_45070
Ki
18±n/a nM
Citation
 Ponticello, GS; Freedman, MB; Habecker, CN; Lyle, PA; Schwam, H; Varga, SL; Christy, ME; Randall, WC; Baldwin, JJ Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors. J Med Chem 30:591-7 (1987) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50024223
Synonyms:
6-Hydroxy-4,4-dioxo-4,5,6,7-tetrahydro-4lambda*6*-thieno[3,2-b]thiopyran-2-sulfonic acid amide | CHEMBL155420
Type:
Small organic molecule
Emp. Form.:
C7H9NO5S3
Mol. Mass.:
283.345
SMILES:
NS(=O)(=O)c1cc2c(CC(O)CS2(=O)=O)s1
Structure:
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