Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50022831
Substrate
n/a
Meas. Tech.
ChEMBL_54565 (CHEMBL664879)
KON
12000000 M-1s-1
Citation
 Taira, K; Benkovic, SJ Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. J Med Chem 31:129-37 (1988) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (F31V) | dfrA17
Type:
n/a
Mol. Mass.:
17532.46
Organism:
Escherichia coli
Description:
n/a
Residue:
157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
  
Inhibitor
Name:
BDBM50022831
Synonyms:
6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143
Type:
Small organic molecule
Emp. Form.:
C8H10N6
Mol. Mass.:
190.2052
SMILES:
Cc1nc2nc(N)nc(N)c2nc1C
Structure:
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