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Target
Dihydrofolate reductase
Ligand
BDBM50020099
Substrate
n/a
Meas. Tech.
ChEBML_54452
IC50
23±n/a nM
Citation
 Rosowsky, A; Bader, H; Kohler, W; Freisheim, JH; Moran, RG Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids. J Med Chem 31:1338-44 (1988) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50020099
Synonyms:
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-nonanedioic acid | CHEMBL283062
Type:
Small organic molecule
Emp. Form.:
C24H30N8O5
Mol. Mass.:
510.5456
SMILES:
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCCCCCC(O)=O)C(O)=O
Structure:
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