Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50367708
Substrate
n/a
Meas. Tech.
ChEBML_195941
IC50
6.5±n/a nM
Citation
 Thaisrivongs, S; Pals, DT; Turner, SR; Kroll, LT Conformationally constrained renin inhibitory peptides: gamma-lactam-bridged dipeptide isostere as conformational restriction. J Med Chem 31:1369-76 (1988) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50367708
Synonyms:
CHEMBL1790106
Type:
Small organic molecule
Emp. Form.:
C49H70N6O7
Mol. Mass.:
855.1161
SMILES:
CCCC[C@H](N1CCC(Cc2ccccc2)(NC(=O)OCc2ccccc2)C1=O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C(C)C)C(=O)N[C@@H]([C@H](C)CC)C(=O)NCc1ccccn1
Structure:
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