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Target
D(2) dopamine receptor
Ligand
BDBM50020141
Substrate
n/a
Meas. Tech.
ChEBML_62891
Ki
1925±n/a nM
Citation
 Abou-Gharbia, M; Patel, UR; Webb, MB; Moyer, JA; Andree, TH; Muth, EA Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies. J Med Chem 31:1382-92 (1988) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50020141
Synonyms:
4-{4-[4-(6-chloro-3-pyridazinyl)hexahydro-1-pyrazinyl]butyl}-4-azatetracyclo[5.4.2.02,6.08,11]tridec-12-ene-3,5-dione;Hydrochloride | CHEMBL424409
Type:
Small organic molecule
Emp. Form.:
C24H30ClN5O2
Mol. Mass.:
455.98
SMILES:
Clc1ccc(nn1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CCC43)C2=O)CC1 |c:22,(16.79,-27.32,;15.48,-26.56,;14.14,-27.32,;12.82,-26.55,;12.82,-25.01,;14.16,-24.25,;15.48,-25.03,;11.5,-24.22,;10.16,-24.99,;8.84,-24.22,;8.85,-22.71,;7.53,-21.94,;6.19,-22.71,;4.85,-21.94,;3.53,-22.71,;2.19,-21.94,;2.03,-20.41,;3.17,-19.38,;.52,-20.08,;-.25,-21.43,;-1.79,-21.44,;-.47,-20.66,;-1.56,-19.57,;-.25,-18.75,;-1.79,-18.75,;-3.13,-17.98,;-3.9,-19.31,;-2.56,-20.09,;.78,-22.56,;.46,-24.06,;10.16,-21.92,;11.51,-22.69,)|
Structure:
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