Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50020124
Substrate
n/a
Meas. Tech.
ChEBML_1423
Ki
162±n/a nM
Citation
 Abou-Gharbia, M; Patel, UR; Webb, MB; Moyer, JA; Andree, TH; Muth, EA Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies. J Med Chem 31:1382-92 (1988) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50020124
Synonyms:
4-{4-[4-(6-chloro-2-pyrazinyl)hexahydro-1-pyrazinyl]butyl}-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene-3,5-dione;Hydrochloride | CHEMBL29155
Type:
Small organic molecule
Emp. Form.:
C23H28ClN5O2
Mol. Mass.:
441.954
SMILES:
Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CC43)C2=O)CC1 |c:22,(25.81,-7.96,;25.81,-6.42,;27.16,-5.67,;27.18,-4.13,;25.84,-3.34,;24.52,-4.11,;24.5,-5.65,;23.18,-3.34,;23.18,-1.81,;21.86,-1.04,;20.52,-1.81,;19.21,-1.04,;17.86,-1.81,;16.54,-1.04,;15.2,-1.81,;13.88,-1.04,;12.45,-1.67,;12.15,-3.17,;11.42,-.52,;12.21,.82,;11.44,2.15,;10.11,1.34,;11.2,.25,;9.88,-.54,;9.11,.8,;8.33,2.15,;9.88,2.15,;13.7,.48,;14.85,1.53,;20.52,-3.34,;21.84,-4.11,)|
Structure:
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