Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50016963
Substrate
n/a
Meas. Tech.
ChEBML_58528
IC50
306±n/a nM
Citation
 New, JS; Christopher, WL; Yevich, JP; Butler, R; Schlemmer, RF; VanderMaelen, CP; Cipollina, JA The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity. J Med Chem 32:1147-56 (1989) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50016963
Synonyms:
2-[4-(4-Thieno[3,2-c]pyridin-4-yl-piperazin-1-yl)-butyl]-isoindole-1,3-dione; hydrochloride | CHEMBL554473
Type:
Small organic molecule
Emp. Form.:
C23H24N4O2S
Mol. Mass.:
420.527
SMILES:
O=C1N(CCCCN2CCN(CC2)c2nccc3sccc23)C(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: