Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM50017063
Substrate
n/a
Meas. Tech.
ChEBML_146883
IC50
>10000±n/a nM
Citation
 Fujimoto, RA; Boxer, J; Jackson, RH; Simke, JP; Neale, RF; Snowhill, EW; Barbaz, BJ; Williams, M; Sills, MA Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides. J Med Chem 32:1259-65 (1989) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50017063
Synonyms:
4-Bromo-N-(1-methyl-1-aza-spiro[4.5]dec-6-yl)-benzamide; hydrochloride | CHEMBL542069
Type:
Small organic molecule
Emp. Form.:
C17H23BrN2O
Mol. Mass.:
351.281
SMILES:
CN1CCC[C@@]11CCCC[C@@H]1NC(=O)c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: