Reaction Details Report a problem with these data
Target
Aminopeptidase B
Ligand
BDBM50017480
Substrate
n/a
Meas. Tech.
ChEMBL_35351 (CHEMBL647933)
Ki
0.840000±n/a nM
Citation
 Harbeson, SL; Rich, DH Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements. J Med Chem 32:1378-92 (1989) [PubMed]  Article 
Target
Name:
Aminopeptidase B
Synonyms:
AMPB_RAT | Ap-B | Arginine aminopeptidase | Arginyl aminopeptidase | Cytosol aminopeptidase IV | Rnpep
Type:
PROTEIN
Mol. Mass.:
72609.93
Organism:
Rattus norvegicus
Description:
ChEMBL_1344423
Residue:
650
Sequence:
MESSGPSSCHSAARRPLHSAQAVDVASASSFRAFEILHLHLDLRAEFGPPGPGPGSRGLNGKATLELRCLLPEGASELRLDSHSCLEVMAATLLRGQPGDQQQLTEPVPFHTQPFSHYGQALCVVFPKPCCAAERFRLELTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALVEVPDGFTAVMSASTWERRGPNKFFFQMSQPIPSYLIALAIGDLASAEVGPRSRVWAEPCLIEAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDVSGEENPLNKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQEQFDKFLKAYVDEFKFQSILAEDFLEFYLEYFPELKKKGVDSIPGFEFNRWLNTPGWPPYLPDLSPGDSLMKPAEELAELWAASEPDMQAIEAVAISTWKTYQLVYFLDKILQKSPLPPGNVKKLGETYPKISNAQNAELRLRWGQIILKNDHQEEFWKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKETFSATASQLHSNVVNYVQQILAPKGS
  
Inhibitor
Name:
BDBM50017480
Synonyms:
5-Amino-8-guanidino-2-(4-hydroxy-benzyl)-4-oxo-octanoic acid | CHEMBL281437
Type:
Small organic molecule
Emp. Form.:
C16H24N4O4
Mol. Mass.:
336.3862
SMILES:
N[C@@H](CCCNC(N)=N)C(=O)C[C@@H](Cc1ccc(O)cc1)C(O)=O
Structure:
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