Reaction Details Report a problem with these data
Target
Beta-1 adrenergic receptor
Ligand
BDBM50010833
Substrate
n/a
Meas. Tech.
ChEBML_56503
IC50
2400±n/a nM
Citation
 Lis, R; Morgan, TK; Marisca, AJ; Gomez, RP; Lind, JM; Davey, DD; Phillips, GB; Sullivan, ME Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity. J Med Chem 33:2883-91 (1990) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50010833
Synonyms:
CHEMBL552615 | CHEMBL99585 | Ersentilide | N-(4-{2-Hydroxy-3-[2-(4-imidazol-1-yl-phenoxy)-ethylamino]-propoxy}-phenyl)-methanesulfonamide; hydrochloride | N-[4-(2-Hydroxy-3-{2-[4-(3H-imidazol-1-yl)-phenoxy]-ethylamino}-propoxy)-phenyl]-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C21H26N4O5S
Mol. Mass.:
446.52
SMILES:
CS(=O)(=O)Nc1ccc(OCC(O)CNCCOc2ccc(cc2)-n2ccnc2)cc1
Structure:
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