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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50015692
Substrate
n/a
Meas. Tech.
ChEBML_49342
IC50
137±n/a nM
Citation
 Kline, RH; Wright, J; Fox, KM; Eldefrawi, ME Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake. J Med Chem 33:2024-7 (1990) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
Dopamine transporter | SC6A3_BOVIN | SLC6A3 | Sodium-dependent dopamine transporter
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75707.43
Organism:
BOVINE
Description:
Dopamine Transporter SLC6A3 BOVINE::P27922
Residue:
693
Sequence:
MSEGRCSVAHMSSVVAPAKEANAMGPKAVELVLVKEQNGVQLTNSTLLNPPQSPTEAQDRETWSKKADFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVVAGVPLFYMELALGQFNREGAAGVWKICPILRGVGYTAILISLYIGFFYNVIIAWALHYLLSSFTTELPWTHCNHSWNSPRCSDARAPNASSGPNGTSRTTPAAEYFERGVLHLHESQGIDDLGPPRWQLTSCLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLFALLLRGITLPGAVDAIRAYLSVDFHRLCEASVWIDAAIQICFSLGVGLGVLIAFSSYNKFTNNCYRDAIITTSVNSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEALATLPLSSVWAVVFFVMLLTLGIDSAMGGMESVITGLADEFQLLHRHRELFTLLVVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLMEVIGVAWFYGVWQFSDDIKQMTGRRPSLYWRLCWKFVSPCFLLFVVVVSIATFRPPHYGAYVFPEWATALGWAIAASSMSVVPIYAAYKLCSLPGSSREKLAYAITPETEHGRVDSGGGAPVHAPPLARGVGRWRKRKSCWVPSRGPGRGGPPTPSPRLAGHTRAFPWTGAPPVPRELTPPSTCRCVPPLVCAHPAVESTGLCSVY
  
Inhibitor
Name:
BDBM50015692
Synonyms:
8-Methyl-3-(4-nitro-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL60609
Type:
Small organic molecule
Emp. Form.:
C16H20N2O4
Mol. Mass.:
304.341
SMILES:
COC(=O)C1C2CCC(CC1c1ccc(cc1)[N+]([O-])=O)N2C |TLB:2:4:20:6.7,11:10:20:6.7|
Structure:
Search PDB for entries with ligand similarity: