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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50015695
Substrate
n/a
Meas. Tech.
ChEBML_49342
IC50
192±n/a nM
Citation
 Kline, RH; Wright, J; Fox, KM; Eldefrawi, ME Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake. J Med Chem 33:2024-7 (1990) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
Dopamine transporter | SC6A3_BOVIN | SLC6A3 | Sodium-dependent dopamine transporter
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75707.43
Organism:
BOVINE
Description:
Dopamine Transporter SLC6A3 BOVINE::P27922
Residue:
693
Sequence:
MSEGRCSVAHMSSVVAPAKEANAMGPKAVELVLVKEQNGVQLTNSTLLNPPQSPTEAQDRETWSKKADFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVVAGVPLFYMELALGQFNREGAAGVWKICPILRGVGYTAILISLYIGFFYNVIIAWALHYLLSSFTTELPWTHCNHSWNSPRCSDARAPNASSGPNGTSRTTPAAEYFERGVLHLHESQGIDDLGPPRWQLTSCLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLFALLLRGITLPGAVDAIRAYLSVDFHRLCEASVWIDAAIQICFSLGVGLGVLIAFSSYNKFTNNCYRDAIITTSVNSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEALATLPLSSVWAVVFFVMLLTLGIDSAMGGMESVITGLADEFQLLHRHRELFTLLVVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLMEVIGVAWFYGVWQFSDDIKQMTGRRPSLYWRLCWKFVSPCFLLFVVVVSIATFRPPHYGAYVFPEWATALGWAIAASSMSVVPIYAAYKLCSLPGSSREKLAYAITPETEHGRVDSGGGAPVHAPPLARGVGRWRKRKSCWVPSRGPGRGGPPTPSPRLAGHTRAFPWTGAPPVPRELTPPSTCRCVPPLVCAHPAVESTGLCSVY
  
Inhibitor
Name:
BDBM50015695
Synonyms:
3-(4-Amino-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL302855
Type:
Small organic molecule
Emp. Form.:
C16H22N2O2
Mol. Mass.:
274.3581
SMILES:
COC(=O)C1C2CCC(CC1c1ccc(N)cc1)N2C |TLB:11:10:18:6.7,THB:2:4:18:6.7|
Structure:
Search PDB for entries with ligand similarity: