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Target
Thymidylate synthase
Ligand
BDBM50015696
Substrate
n/a
Meas. Tech.
ChEBML_209960
IC50
2400±n/a nM
Citation
 McNamara, DJ; Berman, EM; Fry, DW; Werbel, LM Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines. J Med Chem 33:2045-51 (1990) [PubMed]  Article 
Target
Name:
Thymidylate synthase
Synonyms:
TS | TSase | TYSY_MOUSE | Tyms
Type:
PROTEIN
Mol. Mass.:
34957.15
Organism:
Mus musculus
Description:
ChEMBL_1340097
Residue:
307
Sequence:
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
  
Inhibitor
Name:
BDBM50015696
Synonyms:
6-{[(4-Acetyl-phenyl)-prop-2-ynyl-amino]-methyl}-3H-quinazolin-4-one | CHEMBL64215
Type:
Small organic molecule
Emp. Form.:
C20H17N3O2
Mol. Mass.:
331.3679
SMILES:
CC(=O)c1ccc(cc1)N(CC#C)Cc1ccc2nc[nH]c(=O)c2c1
Structure:
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