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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50015722
Substrate
n/a
Meas. Tech.
ChEBML_140172
Kd
10±n/a nM
Citation
 Cereda, E; Ezhaya, A; Gil Quintero, M; Bellora, E; Dubini, E; Micheletti, R; Schiavone, A; Brambilla, A; Schiavi, GB; Donetti, A Synthesis and biological evaluation of new antimuscarinic compounds with amidine basic centers. A useful bioisosteric replacement of classical cationic heads. J Med Chem 33:2108-13 (1990) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50015722
Synonyms:
3-Hydroxy-2-phenyl-propionic acid 8-(1-imino-ethyl)-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride | CHEMBL553783
Type:
Small organic molecule
Emp. Form.:
C18H24N2O3
Mol. Mass.:
316.3948
SMILES:
CC(=N)N1C2CCC1CC(C2)OC(=O)C(CO)c1ccccc1
Structure:
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