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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50005542
Substrate
n/a
Meas. Tech.
ChEMBL_61488 (CHEMBL672390)
IC50
43±n/a nM
Citation
 Milius, RA; Saha, JK; Madras, BK; Neumeyer, JL Synthesis and receptor binding of N-substituted tropane derivatives. High-affinity ligands for the cocaine receptor. J Med Chem 34:1728-31 (1991) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50005542
Synonyms:
3-(4-Fluoro-phenyl)-8-propyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL416818
Type:
Small organic molecule
Emp. Form.:
C18H24FNO2
Mol. Mass.:
305.3871
SMILES:
CCCN1C2CCC1C([C@H](C2)c1ccc(F)cc1)C(=O)OC |TLB:18:8:3:6.5,11:9:3:6.5,THB:2:3:8.9.10:6.5|
Structure:
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