Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50009253
Substrate
n/a
Meas. Tech.
ChEMBL_159774 (CHEMBL763099)
IC50
2±n/a nM
Citation
 Huff, JR HIV protease: a novel chemotherapeutic target for AIDS. J Med Chem 34:2305-14 (1991) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50009253
Synonyms:
2N-(tert-butyl)-1-[3-[2-carbamoyl-1-(2-quinolylcarboxamido)-(1S)-ethylcarboxamido]-2-hydroxy-4-phenyl-(3S)-butyl]hexahydro-2-pyridinecarboxamide | CHEMBL3350611
Type:
Small organic molecule
Emp. Form.:
C34H44N6O5
Mol. Mass.:
616.7504
SMILES:
CC(C)(C)NC(=O)C1CCCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1
Structure:
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