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Target
Renin
Ligand
BDBM50006862
Substrate
n/a
Meas. Tech.
ChEBML_195741
IC50
14±n/a nM
Citation
 Patt, WC; Hamilton, HW; Taylor, MD; Ryan, MJ; Taylor, DG; Connolly, CJ; Doherty, AM; Klutchko, SR; Sircar, I; Steinbaugh, BA Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. J Med Chem 35:2562-72 (1992) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50006862
Synonyms:
4-{3-(2-Amino-thiazol-4-yl)-2-[2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-propionylamino}-3-hydroxy-6-methyl-heptanoic acid (2-methyl-butyl)-amide | CHEMBL316176
Type:
Small organic molecule
Emp. Form.:
C32H51N7O7S2
Mol. Mass.:
709.92
SMILES:
CC[C@@H](C)CNC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1csc(N)n1)NC(=O)[C@H](Cc1ccccc1)NS(=O)(=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: