Reaction Details Report a problem with these data
Target
Hydroxyacylglutathione hydrolase, mitochondrial
Ligand
BDBM50039108
Substrate
n/a
Meas. Tech.
ChEMBL_71297 (CHEMBL686102)
Ki
3400±n/a nM
Citation
 Murthy, NS; Bakeris, T; Kavarana, MJ; Hamilton, DS; Lan, Y; Creighton, DJ S-(N-aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II. J Med Chem 37:2161-6 (1994) [PubMed]  Article 
Target
Name:
Hydroxyacylglutathione hydrolase, mitochondrial
Synonyms:
GLO2 | GLO2_HUMAN | Glyoxalase II | HAGH | HAGH1
Type:
PROTEIN
Mol. Mass.:
33815.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71296
Residue:
308
Sequence:
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
  
Inhibitor
Name:
BDBM50039108
Synonyms:
S-(N-Hydroxy-N-(4-chlorophenyl)carbamoyl)glutathione
Type:
Small organic molecule
Emp. Form.:
C17H20ClN4O8S
Mol. Mass.:
475.881
SMILES:
[NH3+]C(CCC(=O)NC(CSC(=O)N(O)c1ccc(Cl)cc1)C(=O)NCC([O-])=O)C([O-])=O
Structure:
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