Reaction Details Report a problem with these data
Target
Lactoylglutathione lyase
Ligand
BDBM50039109
Substrate
n/a
Meas. Tech.
ChEMBL_71294 (CHEMBL684998)
Ki
2230000±n/a nM
Citation
 Murthy, NS; Bakeris, T; Kavarana, MJ; Hamilton, DS; Lan, Y; Creighton, DJ S-(N-aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II. J Med Chem 37:2161-6 (1994) [PubMed]  Article 
Target
Name:
Lactoylglutathione lyase
Synonyms:
Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:
Enzyme
Mol. Mass.:
20772.95
Organism:
Homo sapiens (Human)
Description:
Q04760
Residue:
184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
  
Inhibitor
Name:
BDBM50039109
Synonyms:
S-D-Lactoylglutathione
Type:
Small organic molecule
Emp. Form.:
C8H12NO6S
Mol. Mass.:
250.25
SMILES:
C[C@@H](O)C(=O)SCC(C([NH3+])C([O-])=O)C([O-])=O
Structure:
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