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Target
Translocator protein
Ligand
BDBM50041487
Substrate
n/a
Meas. Tech.
ChEMBL_37642 (CHEMBL650286)
IC50
813±n/a nM
Citation
 Greco, G; Novellino, E; Fiorini, I; Nacci, V; Campiani, G; Ciani, SM; Garofalo, A; Bernasconi, P; Mennini, T A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor. J Med Chem 37:4100-8 (1995) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50041487
Synonyms:
CHEMBL33619 | Propionic acid 9-chloro-5-phenyl-6-thia-10b-aza-benzo[e]azulen-4-yl ester
Type:
Small organic molecule
Emp. Form.:
C21H16ClNO2S
Mol. Mass.:
381.875
SMILES:
CCC(=O)OC1=C(Sc2ccc(Cl)cc2-n2cccc12)c1ccccc1 |t:5|
Structure:
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