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Target
D(2) dopamine receptor
Ligand
BDBM50038287
Substrate
n/a
Meas. Tech.
ChEMBL_58687 (CHEMBL672653)
IC50
443±n/a nM
Citation
 Wustrow, DJ; Wise, LD; Cody, DM; MacKenzie, RG; Georgic, LM; Pugsley, TA; Heffner, TG Studies of the active conformation of a novel series of benzamide dopamine D2 agonists. J Med Chem 37:4251-7 (1995) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50038287
Synonyms:
CHEMBL135387 | N-{4-[2-(4-Pyridin-2-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-benzamide
Type:
Small organic molecule
Emp. Form.:
C24H32N4O
Mol. Mass.:
392.5371
SMILES:
O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccccn2)CC1)c1ccccc1 |wU:3.2,wD:6.6,(5.2,-2.8,;5.21,-4.34,;6.56,-5.08,;7.87,-4.31,;7.86,-2.77,;9.19,-2,;10.53,-2.77,;11.87,-1.99,;13.2,-2.74,;14.53,-1.97,;15.86,-2.74,;17.2,-1.97,;17.2,-.43,;15.86,.34,;14.51,-.45,;18.52,.34,;19.87,-.45,;21.19,.32,;21.21,1.86,;19.87,2.63,;18.52,1.86,;10.53,-4.31,;9.22,-5.08,;3.89,-5.11,;2.55,-4.34,;1.22,-5.13,;1.23,-6.67,;2.58,-7.42,;3.89,-6.65,)|
Structure:
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