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Target
Type 1 InsP3 receptor isoform S2
Ligand
BDBM50040911
Substrate
n/a
Meas. Tech.
ChEMBL_90091 (CHEMBL702008)
pH
6.8±n/a
IC50
78±n/a nM
Comments
extracted
Citation
 Kozikowski, AP; Fauq, AH; Wilcox, RA; Challiss, RA; Nahorski, SR The novel Ins(1,4,5)P3 analogue 3-amino-3-deoxy-Ins(1,4,5)P3: a pH-dependent Ins(1,4,5)P3 receptor partial agonist in SH-SY5Y neuroblastoma cells. J Med Chem 37:868-72 (1994) [PubMed]  Article 
Target
Name:
Type 1 InsP3 receptor isoform S2
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
19087.24
Organism:
Sus scrofa
Description:
ChEMBL_90089
Residue:
174
Sequence:
FICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKLISIDELDNAELPQAPDSENSTEQELEPSPPLRQLEDHKRGEALRQILVNRYYGNIRPSGRRESLTSFGNGPLSPGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESI
  
Inhibitor
Name:
BDBM50040911
Synonyms:
(+)-myo-inositol 1,4,5-trisphosphorothioate | (-)-chiro-inositol 1,4,6-trisphosphorothioate | 1,4,5-trisphosphate 5-phosphatase derivatives | Inositol 1,4,5-trisphosphorothioate | L-(1,4,5)PS3 | {[2,5-bis({[dioxido(sulfanylidene)--phosphanyl]oxy})-3,4,6-trihydroxycyclohexyl]oxy}(sulfanylidene)phosphonite
Type:
Small organic molecule
Emp. Form.:
C6H9O12P3S3
Mol. Mass.:
462.248
SMILES:
OC1C(O)C(OP([O-])([O-])=S)C(OP([O-])([O-])=S)C(O)C1OP([O-])([O-])=S
Structure:
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