Reaction Details Report a problem with these data
Target
Spermidine synthase
Ligand
BDBM50369035
Substrate
n/a
Meas. Tech.
ChEMBL_160082 (CHEMBL768498)
IC50
3±n/a nM
Citation
 Lakanen, JR; Pegg, AE; Coward, JK Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase. J Med Chem 38:2714-27 (1995) [PubMed]  Article 
Target
Name:
Spermidine synthase
Synonyms:
SPEE_HUMAN | SPS1 | SRM | SRML1
Type:
PROTEIN
Mol. Mass.:
33818.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_201176
Residue:
302
Sequence:
MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS
  
Inhibitor
Name:
BDBM50369035
Synonyms:
CHEMBL608868
Type:
Small organic molecule
Emp. Form.:
C18H32N8O3
Mol. Mass.:
408.4985
SMILES:
NCCCCNC(CCN)CC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
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