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Target
Spermidine synthase
Ligand
BDBM50095450
Substrate
n/a
Meas. Tech.
ChEMBL_160081 (CHEMBL768497)
IC50
250±n/a nM
Citation
 Lakanen, JR; Pegg, AE; Coward, JK Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase. J Med Chem 38:2714-27 (1995) [PubMed]  Article 
Target
Name:
Spermidine synthase
Synonyms:
SPEE_HUMAN | SPS1 | SRM | SRML1
Type:
PROTEIN
Mol. Mass.:
33818.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_201176
Residue:
302
Sequence:
MEPGPDGPAASGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS
  
Inhibitor
Name:
BDBM50095450
Synonyms:
2-[6-Amino-1-(2-amino-ethyl)-hexylsulfanylmethyl]-5-(6-amino-purin-9-yl)-tetrahydro-furan-3,4-diol | CHEMBL330673
Type:
Small organic molecule
Emp. Form.:
C18H31N7O3S
Mol. Mass.:
425.549
SMILES:
NCCCCCC(CCN)SC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
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