Reaction Details Report a problem with these data
Target
Alpha-1A adrenergic receptor
Ligand
BDBM66983
Substrate
n/a
Meas. Tech.
ChEMBL_33729 (CHEMBL647045)
Ki
449±n/a nM
Citation
 Ruffolo, RR; Bondinell, W; Hieble, JP Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem 38:3681-716 (1995) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM66983
Synonyms:
6-chloranyl-3-methyl-1,2,4,5-tetrahydro-3-benzazepine;hydrochloride | 6-chloro-3-methyl-1,2,4,5-tetrahydro-3-benzazepine;hydrochloride | CHEMBL123349 | MLS002172470 | SKF 86466 | SKF-86466 hydrochloride | SMR001254100 | cid_10220250
Type:
Small organic molecule
Emp. Form.:
C11H14ClN
Mol. Mass.:
195.689
SMILES:
CN1CCc2cccc(Cl)c2CC1
Structure:
Search PDB for entries with ligand similarity: