Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50036437
Substrate
n/a
Meas. Tech.
ChEMBL_2814 (CHEMBL617843)
Ki
8±n/a nM
Citation
 Phillips, ST; de Paulis, T; Neergaard, JR; Baron, BM; Siegel, BW; Seeman, P; Van Tol, HH; Guan, HC; Smith, HE Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors. J Med Chem 38:708-14 (1995) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2c) | 5HT2C_RAT | 5ht1c | Htr1c | Htr2c | Serotonin (5-HT) receptor | Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
Type:
Enzyme
Mol. Mass.:
51935.10
Organism:
Rattus norvegicus (Rat)
Description:
P08909
Residue:
460
Sequence:
MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
  
Inhibitor
Name:
BDBM50036437
Synonyms:
4-Dibenzo[b,f]oxepin-10-yl-1-methyl-piperidine; hydrochloride | CHEMBL539057
Type:
Small organic molecule
Emp. Form.:
C20H21NO
Mol. Mass.:
291.3868
SMILES:
CN1CCC(CC1)C1=Cc2ccccc2Oc2ccccc12 |t:8|
Structure:
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