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Target
Mu-type opioid receptor
Ligand
BDBM50034607
Substrate
n/a
Meas. Tech.
ChEMBL_148687 (CHEMBL751061)
IC50
67±n/a nM
Citation
 Bertha, CM; Flippen-Anderson, JL; Rothman, RB; Porreca, F; Davis, P; Xu, H; Becketts, K; Cha, XY; Rice, KC Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands. J Med Chem 38:1523-37 (1995) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50034607
Synonyms:
3-[13-heptyl-9,13-diazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3(8),4,6-tetraen-1-yl]phenol | CHEMBL39531
Type:
Small organic molecule
Emp. Form.:
C27H34N2O
Mol. Mass.:
402.5717
SMILES:
CCCCCCCN1CCC2(CC1Cc1[nH]c3ccccc3c21)c1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity: