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Target
Integrase
Ligand
BDBM499
Substrate
n/a
Meas. Tech.
ChEMBL_90733 (CHEMBL701285)
IC50
10500±n/a nM
Citation
 Mazumder, A; Wang, S; Neamati, N; Nicklaus, M; Sunder, S; Chen, J; Milne, GW; Rice, WG; Burke, TR; Pommier, Y Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease. J Med Chem 39:2472-81 (1996) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM499
Synonyms:
6-hexyl-3-[(6-hexyl-4,7-dihydroxy-2-oxo-3,4-dihydro-2H-1-benzopyran-3-yl)(phenyl)methyl]-4,7-dihydroxy-2H-chromen-2-one | CHEMBL64802 | Cancer Chemotherapy National Service Center (CCNSC) compound 32180 | NSC 32180
Type:
Small organic molecule
Emp. Form.:
C37H42O8
Mol. Mass.:
614.7246
SMILES:
CCCCCCc1cc2C(O)C(C(c3ccccc3)c3c(O)c4cc(CCCCCC)c(O)cc4oc3=O)C(=O)Oc2cc1O
Structure:
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