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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50052557
Substrate
n/a
Meas. Tech.
ChEMBL_828 (CHEMBL615828)
IC50
173±n/a nM
Citation
 Perrone, R; Berardi, F; Leopoldo, M; Tortorella, V; Fornaretto, MG; Caccia, C; McArthur, RA 1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3. J Med Chem 39:3195-202 (1996) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50052557
Synonyms:
5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid [2-(4-pyridin-2-yl-piperazin-1-yl)-ethyl]-amide | CHEMBL107503
Type:
Small organic molecule
Emp. Form.:
C23H30N4O2
Mol. Mass.:
394.5099
SMILES:
COc1cccc2C(CCCc12)C(=O)NCCN1CCN(CC1)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: