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Target
Type-2 angiotensin II receptor
Ligand
BDBM50049202
Substrate
n/a
Meas. Tech.
ChEMBL_35421 (CHEMBL643595)
IC50
12±n/a nM
Citation
 Wexler, RR; Greenlee, WJ; Irvin, JD; Goldberg, MR; Prendergast, K; Smith, RD; Timmermans, PB Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J Med Chem 39:625-56 (1996) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50049202
Synonyms:
(2S,3R)-2-({(S)-1-[(S)-2-[(S)-2-[(S)-2-Benzoylamino-3-(4-hydroxy-phenyl)-propionylamino]-6-((S)-2-benzyloxycarbonylamino-5-guanidino-pentanoylamino)-hexanoylamino]-3-(3H-imidazol-4-yl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-methyl-pentanoic acid | CGP-42112A | CHEMBL267354
Type:
Small organic molecule
Emp. Form.:
C53H70N12O11
Mol. Mass.:
1051.1967
SMILES:
CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(O)=O
Structure:
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