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Target
Neuromedin-K receptor
Ligand
BDBM50052524
Substrate
n/a
Meas. Tech.
ChEMBL_209536 (CHEMBL813866)
IC50
12±n/a nM
Citation
 Boden, P; Eden, JM; Hodgson, J; Horwell, DC; Hughes, J; McKnight, AT; Lewthwaite, RA; Pritchard, MC; Raphy, J; Meecham, K; Ratcliffe, GS; Suman-Chauhan, N; Woodruff, GN Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists. J Med Chem 39:1664-75 (1996) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK3R_CAVPO | Neurokinin 3 receptor | Neurokinin NK3 | Neuromedin-K receptor | TACR3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49456.44
Organism:
GUINEA PIG
Description:
Neurokinin NK3 TACR3 GUINEA PIG::P30098
Residue:
440
Sequence:
MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDELELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSKSTSTTASFVSSSHMSVEEGS
  
Inhibitor
Name:
BDBM50052524
Synonyms:
(S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-3-(3-carboxy-propionylamino)-succinamic acid | CHEMBL106124 | senktide
Type:
Small organic molecule
Emp. Form.:
C40H55N7O11S
Mol. Mass.:
841.97
SMILES:
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O
Structure:
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