Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50058153
Substrate
n/a
Meas. Tech.
ChEMBL_148519 (CHEMBL758129)
Ki
125±n/a nM
Citation
 Ohkawa, S; DiGiacomo, B; Larson, DL; Takemori, AE; Portoghese, PS 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. J Med Chem 40:1720-5 (1997) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44431.62
Organism:
MOUSE
Description:
OPIATE Mu OPRM1 MOUSE::P42866
Residue:
398
Sequence:
MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50058153
Synonyms:
7-(5',6'-Benzo-2'-spiroindanyl)oxymorphone | CHEMBL297470
Type:
Small organic molecule
Emp. Form.:
C29H27NO4
Mol. Mass.:
453.529
SMILES:
CN1CCC23C4Oc5c2c(CC1[C@]3(O)CC1(Cc2cc3ccccc3cc2C1)C4=O)ccc5O |TLB:13:12:8.9.10:1.3.2,THB:7:8:12:1.3.2,0:1:12:8.9.10|
Structure:
Search PDB for entries with ligand similarity: