Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50059262
Substrate
n/a
Meas. Tech.
ChEMBL_124226 (CHEMBL733981)
IC50
2000±n/a nM
Citation
 Harfenist, M; Joseph, DM; Spence, SC; Mcgee, DP; Reeves, MD; White, HL Selective inhibitors of monoamine oxidase. 4. SAR of tricyclic N-methylcarboxamides and congeners binding at the tricyclics' hydrophilic binding site. J Med Chem 40:2466-73 (1997) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rattus norvegicus (rat)
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM50059262
Synonyms:
1-(7-Acetyl-10,10-dioxo-10H-10lambda*6*-phenoxathiin-2-yl)-ethanone | CHEMBL81680
Type:
Small organic molecule
Emp. Form.:
C16H12O5S
Mol. Mass.:
316.328
SMILES:
CC(=O)c1ccc2c(Oc3ccc(cc3S2(=O)=O)C(C)=O)c1
Structure:
Search PDB for entries with ligand similarity: