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Target
Metabotropic glutamate receptor 6
Ligand
BDBM50052553
Substrate
n/a
Meas. Tech.
ChEMBL_104459 (CHEMBL712802)
EC50
140000±n/a nM
Citation
 Ahmadian, H; Nielsen, B; Bräuner-Osborne, H; Johansen, TN; Stensbøl, TB; Sløk, FA; Sekiyama, N; Nakanishi, S; Krogsgaard-Larsen, P; Madsen, U (S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors. J Med Chem 40:3700-5 (1997) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 6
Synonyms:
GRM6_RAT | Gprc1f | Grm6 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 6 (mGlu6) | Mglur6 | mGlu6 | metabotropic glutamate 6
Type:
Enzyme
Mol. Mass.:
95095.82
Organism:
Rattus norvegicus (Rat)
Description:
P35349
Residue:
871
Sequence:
MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPQNENAEDAK
  
Inhibitor
Name:
BDBM50052553
Synonyms:
(2S)-2-aminohexanedioic acid | (S)-2-aminohexanedioic acid | CHEMBL88804 | L-2-aminoadipic acid
Type:
Small organic molecule
Emp. Form.:
C6H11NO4
Mol. Mass.:
161.1558
SMILES:
N[C@@H](CCCC(O)=O)C(O)=O
Structure:
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