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Target
Glutathionylspermidine synthase
Ligand
BDBM50060963
Substrate
n/a
Meas. Tech.
ChEMBL_72760 (CHEMBL682574)
Ki
24000±n/a nM
Citation
 Chen, S; Lin, CH; Kwon, DS; Walsh, CT; Coward, JK Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli. J Med Chem 40:3842-50 (1997) [PubMed]  Article 
Target
Name:
Glutathionylspermidine synthase
Synonyms:
GSP | GSP_CRIFA
Type:
PROTEIN
Mol. Mass.:
80299.94
Organism:
Crithidia fasciculata
Description:
ChEMBL_72759
Residue:
719
Sequence:
MSSLPHNHHYETHHRGTAEVPFDELIGVTPDGVPVISNGNEAHFSNLESITAACLPLSSFERKAPCKQPYRKMGVKWQCVEFVRRYLASRKAVWMTSLCTAEEVWREENLFVDVRDGRPVEVVRTPNKSTGPAPAVADIVVWGEGPETPFGHVAIVTEVCASCVRVAEQNQGFEKWPEDVPFSREIAMRTTESGEVELLDEDPLLGWVTVQAPFYNFDDGDLADSFRLVVGQGQILRQPFPKHVDVPWLNTGEECDTILKHSLVVDGNMGEGAHAEEGDVPGAFYFLDYDMFCRLGRAASSLHRIAMAATAKVLEDPESTHLLEHYFGVPPEIQPLLRRSWEMTPPMGGRFDFGYDGKNVVMLEYNCDSSGALLECCNTQEKMARFYGVSQGTSTGSFLGAKCVTYFQRLLTNEKVCPQHRLIHFMIDEDDEERYTARCMMGFAEQAGFRTKLCVKLVNFRYRDGPPSNAAPLATPCDHPTIVDGEDEEVLMVWKTWSWDTVLHQYHSQRSSSDAVNTPTLSDILLNNNIRVLEPLWKAVTGSKAILPFMHALAPDHEHMLAASFLPTREIISRHYISKPVNGRAGQNIMMYDPVTSPTELEGAPQQDICEALSQNASARSLLNGSPLPLSQSVDQTNECSPGKFFDSVLVYQQRLFLKKFDGKYFPIFCGWMVGDEFGGVVVREDTSKITKLSSMVVPARVVRDNVPLGVSYSDEGET
  
Inhibitor
Name:
BDBM50060963
Synonyms:
O-Methyl-N-[3-[N-(4-aminobutyl)amino]propyl][[(glutamylalanyl) amino]methyl]phosphonamidate
Type:
Small organic molecule
Emp. Form.:
C17H39N6O6P
Mol. Mass.:
454.5008
SMILES:
COP(=O)(CNC(=O)[C@H](C)NC(=O)CC[C@H]([NH3+])C([O-])=O)NCCC[NH2+]CCCC[NH3+]
Structure:
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