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Target
Integrase
Ligand
BDBM50056929
Substrate
n/a
Meas. Tech.
ChEMBL_90897 (CHEMBL699510)
IC50
35800±n/a nM
Citation
 Neamati, N; Hong, H; Mazumder, A; Wang, S; Sunder, S; Nicklaus, MC; Milne, GW; Proksa, B; Pommier, Y Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching. J Med Chem 40:942-51 (1997) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50056929
Synonyms:
3,5,3',5'-Tetranitro-biphenyl-4,4'-diol | CHEMBL176916 | NSC-98358
Type:
Small organic molecule
Emp. Form.:
C12H6N4O10
Mol. Mass.:
366.1968
SMILES:
Oc1c(cc(cc1[N+]([O-])=O)-c1cc(c(O)c(c1)[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O
Structure:
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