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Target
Integrase
Ligand
BDBM50056941
Substrate
n/a
Meas. Tech.
ChEMBL_90897 (CHEMBL699510)
IC50
24300±n/a nM
Citation
 Neamati, N; Hong, H; Mazumder, A; Wang, S; Sunder, S; Nicklaus, MC; Milne, GW; Proksa, B; Pommier, Y Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching. J Med Chem 40:942-51 (1997) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50056941
Synonyms:
3-(2,3-Dibromo-4,5-dihydroxy-benzyl)-3,3a,6-trihydroxy-tetrahydro-furo[3,2-b]furan-2-one | CHEMBL368123 | NSC-615490
Type:
Small organic molecule
Emp. Form.:
C13H12Br2O8
Mol. Mass.:
456.038
SMILES:
OC1COC2(O)C1OC(=O)C2(O)Cc1cc(O)c(O)c(Br)c1Br
Structure:
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