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Target
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Ligand
BDBM50057504
Substrate
n/a
Meas. Tech.
ChEMBL_328 (CHEMBL615301)
IC50
8.3±n/a nM
Citation
 Kenny, B; Ballard, S; Blagg, J; Fox, D Pharmacological options in the treatment of benign prostatic hyperplasia. J Med Chem 40:1293-315 (1997) [PubMed]  Article 
Target
Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Synonyms:
3-beta-HSD I | 3-beta-hydroxy-5-ene steroid dehydrogenase | 3-beta-hydroxy-Delta(5)-steroid dehydrogenase | 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I | 3BH | 3BHS1_HUMAN | Delta-5-3-ketosteroid isomerase | HSD3B1 | HSDB3A | Progesterone reductase | Trophoblast antigen FDO161G
Type:
PROTEIN
Mol. Mass.:
42261.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_241
Residue:
373
Sequence:
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGGTLYTCALRPMYIYGEGSRFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSFPLSLMYWIGFLLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKETLKSKTQ
  
Inhibitor
Name:
BDBM50057504
Synonyms:
(1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (3,3-dimethyl-butyl)-amide | CHEMBL24033
Type:
Small organic molecule
Emp. Form.:
C25H40N2O2
Mol. Mass.:
400.5973
SMILES:
CC(C)(C)CCNC(=O)[C@H]1CCC2C3CN=C4CC(=O)CC[C@]4(C)C3CC[C@]12C |t:15|
Structure:
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