Reaction Details Report a problem with these data
Target
Sodium-dependent dopamine transporter
Ligand
BDBM50065001
Substrate
n/a
Meas. Tech.
ChEMBL_61996 (CHEMBL670106)
IC50
2692±n/a nM
Citation
 Avor, KS; Singh, S; Seale, TW; Pouw, B; Basmadjian, GP 2beta-Substituted analogues of 4'-iodococaine: synthesis and dopamine transporter binding potencies. J Med Chem 41:2380-9 (1998) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50065001
Synonyms:
4-Iodo-benzoic acid (2R,3S)-2-ethyl-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester | CHEMBL76253
Type:
Small organic molecule
Emp. Form.:
C17H22INO2
Mol. Mass.:
399.2666
SMILES:
CC[C@@H]1C2CCC(C[C@@H]1OC(=O)c1ccc(I)cc1)N2C |THB:1:2:19:4.5,9:8:19:4.5,20:19:8.2.7:4.5|
Structure:
Search PDB for entries with ligand similarity: