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Target
Beta-lactamase
Ligand
BDBM50067070
Substrate
n/a
Meas. Tech.
ChEMBL_40864 (CHEMBL653618)
IC50
165±n/a nM
Citation
 Hubschwerlen, C; Angehrn, P; Gubernator, K; Page, MG; Specklin, JL Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins. J Med Chem 41:3972-5 (1998) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ENTCL | ampC
Type:
PROTEIN
Mol. Mass.:
41306.67
Organism:
Enterobacter cloacae
Description:
ChEMBL_40258
Residue:
381
Sequence:
MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ
  
Inhibitor
Name:
BDBM50067070
Synonyms:
CHEMBL355579 | sodium salt -tert-butyl 7-oxo-6-(sulfooxy)-2,6-diazabicyclo[3.2.0]heptane-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C10H15N2O7S
Mol. Mass.:
307.301
SMILES:
CC(C)(C)OC(=O)N1CCC2C1C(=O)N2OS([O-])(=O)=O
Structure:
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