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Target
Beta-lactamase
Ligand
BDBM50067068
Substrate
n/a
Meas. Tech.
ChEMBL_41032 (CHEMBL651936)
IC50
217±n/a nM
Citation
 Hubschwerlen, C; Angehrn, P; Gubernator, K; Page, MG; Specklin, JL Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins. J Med Chem 41:3972-5 (1998) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ENTCL | ampC
Type:
PROTEIN
Mol. Mass.:
41306.67
Organism:
Enterobacter cloacae
Description:
ChEMBL_40258
Residue:
381
Sequence:
MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ
  
Inhibitor
Name:
BDBM50067068
Synonyms:
(2S,5R)-2-(4-Carbamoyl-phenylcarbamoyl)-7-oxo-2,6-diaza-bicyclo[3.2.0]heptane-6-sulfonic acid
Type:
Small organic molecule
Emp. Form.:
C13H14N4O6S
Mol. Mass.:
354.338
SMILES:
NC(=O)c1ccc(NC(=O)N2CC[C@@H]3C2C(=O)N3S(O)(=O)=O)cc1
Structure:
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