Reaction Details Report a problem with these data
Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50062778
Substrate
n/a
Meas. Tech.
ChEMBL_154089 (CHEMBL760613)
IC50
107000±n/a nM
Citation
 Moriarty, RM; Enache, LA; Zhao, L; Gilardi, R; Mattson, MV; Prakash, O Rigid phencyclidine analogues. Binding to the phencyclidine and sigma 1 receptors. J Med Chem 41:468-77 (1998) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM50062778
Synonyms:
1-(3,4-Dihydro-2H-1,4-methano-naphthalen-1-yl)-piperidine | CHEMBL356757
Type:
Small organic molecule
Emp. Form.:
C16H21N
Mol. Mass.:
227.3446
SMILES:
C1CC2(CC1c1ccccc21)N1CCCCC1 |THB:9:10:3:1.0,6:5:3:1.0|
Structure:
Search PDB for entries with ligand similarity: