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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50455444
Substrate
n/a
Meas. Tech.
ChEMBL_176336 (CHEMBL784029)
IC50
71±n/a nM
Citation
 Lieske, SF; Yang, B; Eldefrawi, ME; MacKerell, AD; Wright, J (-)-3 beta-Substituted ecgonine methyl esters as inhibitors for cocaine binding and dopamine uptake. J Med Chem 41:864-76 (1998) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50455444
Synonyms:
CHEMBL2112945
Type:
Small organic molecule
Emp. Form.:
C18H25NO2
Mol. Mass.:
287.3966
SMILES:
[H][C@@]12CCC([C@H]([C@H](CCc3ccccc3)C1)C(=O)OC)N2C |r,THB:16:5:20:3.2,7:6:20:3.2,21:20:5.6.15:3.2|
Structure:
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