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Target
Histamine H2 receptor
Ligand
BDBM50079527
Substrate
n/a
Meas. Tech.
ChEMBL_85065 (CHEMBL692776)
IC50
1600±n/a nM
Citation
 Quiñones-Torrelo, C; Sagrado, S; Villanueva-Camañas, RM; Medina-Hernández, MJ Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography. J Med Chem 42:3154-62 (1999) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40567.22
Organism:
Cavia porcellus (domestic guinea pig)
Description:
For the H2 receptor-binding assays, guinea pig striatum was used.
Residue:
359
Sequence:
MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
  
Inhibitor
Name:
BDBM50079527
Synonyms:
(3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine(3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine | CHEMBL101740 | DOXEPIN | cis-doxepin
Type:
Small organic molecule
Emp. Form.:
C19H21NO
Mol. Mass.:
279.3761
SMILES:
CN(C)CC\C=C1\c2ccccc2COc2ccccc12
Structure:
Search PDB for entries with ligand similarity: