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Target
Kappa-type opioid receptor
Ligand
BDBM50088377
Substrate
n/a
Meas. Tech.
ChEMBL_146677 (CHEMBL753169)
Ki
0.42±n/a nM
Citation
 Lavecchia, A; Greco, G; Novellino, E; Vittorio, F; Ronsisvalle, G Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations. J Med Chem 43:2124-34 (2000) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50088377
Synonyms:
1-{2-[3-(3,4-Dichloro-phenyl)-2-oxo-tetrahydro-pyrimidin-1-yl]-2-phenyl-ethyl}-pyrrolidinium
Type:
Small organic molecule
Emp. Form.:
C22H26Cl2N3O
Mol. Mass.:
419.367
SMILES:
Clc1ccc(cc1Cl)N1CCCN([C@H](C[NH+]2CCCC2)c2ccccc2)C1=O
Structure:
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