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Target
Matrilysin
Ligand
BDBM12076
Substrate
n/a
Meas. Tech.
ChEMBL_104915 (CHEMBL713451)
IC50
140±n/a nM
Citation
 O'Brien, PM; Ortwine, DF; Pavlovsky, AG; Picard, JA; Sliskovic, DR; Roth, BD; Dyer, RD; Johnson, LL; Man, CF; Hallak, H Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors. J Med Chem 43:156-66 (2000) [PubMed]  Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM12076
Synonyms:
(2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-hydroxy-3-methylbutanamide | CHEMBL433262 | alpha-arylsulfonylamino hydroxamate 3R
Type:
Small organic molecule
Emp. Form.:
C17H19BrN2O4S
Mol. Mass.:
427.313
SMILES:
CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(=O)NO |r|
Structure:
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