Reaction Details Report a problem with these data
Target
Somatostatin receptor type 4
Ligand
BDBM50369646
Substrate
n/a
Meas. Tech.
ChEMBL_223908 (CHEMBL884900)
IC50
100±n/a nM
Citation
 Liu, J; Underwood, DJ; Cascieri, MA; Rohrer, SP; Cantin, LD; Chicchi, G; Smith, AB; Hirschmann, R Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry. J Med Chem 43:3827-31 (2000) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 4
Synonyms:
SOMATOSTATIN SST4 | SS-4-R | SS4-R | SS4R | SSR4_HUMAN | SST4R | SSTR4 | Somatostatin receptor type 4 (SSTR4)
Type:
Enzyme
Mol. Mass.:
42015.38
Organism:
Homo sapiens (Human)
Description:
P31391
Residue:
388
Sequence:
MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF
  
Inhibitor
Name:
BDBM50369646
Synonyms:
CHEMBL1790896
Type:
Small organic molecule
Emp. Form.:
C46H54N6O7
Mol. Mass.:
802.957
SMILES:
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)C2c3[nH]c4ccccc4c3C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]3CCCC3C(=O)[C@H](Cc3ccccc3)NC1=O)C2=O
Structure:
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